A triosmium carbonyl cluster that inhibits α-synuclein aggregation and disassembles preformed aggregates
Two triosmium carbonyl clusters, <i>viz.</i>, Os<sub>3</sub>(μ-H)(μ-SC<sub>6</sub>H<sub>4</sub>-<i>p</i>-NO<sub>2</sub>)(CO)<sub>10</sub> (1) and Os<sub>3</sub>(μ-H)(<i>kO</i>,μ-<i>O</i>'-2-flavone)(CO)<sub>9</sub> (2), effectively inhibited α-synuclein aggregation, a key signature of Parkinson's disease (PD), in both wild-type and A53T-mutant α-synuclein models. Cluster 2 showed superior efficacy and a significantly better safety profile, and could also disassemble preformed aggregates.
Authors
- Balázs Zoltán Gulyás (ORCID: https://orcid.org/0000-0001-9295-2460)
- Weng Kee Leong (ORCID: https://orcid.org/0000-0003-3198-7111)
- Mathangi Palanivel (ORCID: https://orcid.org/0000-0001-8710-4336)
- Xin Liang (ORCID: https://orcid.org/0009-0008-1376-5500)
Institutions
- Nanyang Technological University (SG)
- Université Bourgogne Franche-Comté (FR)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01141h
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Ministry of Education - Singapore