Exploring the Theoretical Mechanism of Chai Gui Hewei Decoction for the Treatment of Functional Dyspepsia Based on SCF/c-kit Pathway

功能性消化不良(FD)的胃肠动力障碍与Cajal间质细胞(ICC)网络损伤密切相关。文章系统阐述干细胞因子(SCF)/c-kit信号通路在FD发病中的核心作用，提出柴桂和胃方通过三重机制修复ICC网络：1) 柴胡皂苷激活c-kit受体促ICC增殖；2) 桂枝成分抑制肿瘤坏死因子-α (TNF-α)改善炎症微环境；3) 白芍苷调节5-羟色胺(5-HT)信号恢复脑肠轴平衡。基于“肝郁脾虚-ICC功能障碍”病机对应理论，构建中药复方多靶点修复胃肠起搏网络的新假说，为中西医结合治疗提供理论依据。Gastrointestinal dyskinesia in functional dyspepsia (FD) is closely related to the damage of Cajal interstitial cell (ICC) network. In this paper, the central role of the stem cell factor (SCF)/c-kit signaling pathway in the pathogenesis of FD was systematically elucidated, and it was proposed that the Chai Gui Hewei Decoction repaired the ICC network through a three-fold mechanism: 1) Bupleurum saponin activated the c-kit receptor to promote the proliferation of ICC; 2) Cinnamomum cassiae ingredient inhibited the tumor necrosis factor-α (TNF-α) to improve the inflammation microenvironment; 3) Paeonia lactiflora glucoside regulates 5-hydroxytryptamine (5-HT) signaling to restore the balance of brain-gut axis. Based on the theory of “liver depression and spleen deficiency-ICC dysfunction”, a new hypothesis of multi-target repair of gastrointestinal pacing network by traditional Chinese herbal medicine compound was constructed, which provides a theoretical basis for the combination of Chinese and Western medicine.