Modern pathogenetic aspects of urolithiasis development

World experience accumulated in the study of the problem from the standpoint of various fields of knowledge indicates that urolithiasis is probably the most polyetiological disease with a very complex pathogenesis. Despite the successes achieved in the treatment of urolithiasis, relapses of the disease within 5 years can occur in 50% of patients. Today, some genetic polymorphisms associated with urolithiasis are of particular interest: uromodulin, which is involved in the regulation of vitamin D metabolism and calcium metabolism. The study of the problem of urolithiasis has reached a qualitatively new level in recent years due to the use of a multidisciplinary approach and the principles of evidence-based medicine. The expansion of the study of the etiology and pathogenesis of the disease, the development and application of high-tech diagnostic and treatment methods have made it possible to solve many problems.