Small T Oncoprotein of Merkel Cell Polyomavirus Attenuates Cisplatin-Induced Apoptosis and Enhances E1, E6/E7, MMP-1, and Ki-67 Expression in HeLa Cervical Cancer Cells
The presence of MCPyV sT and HPV oncoproteins together enhances resistance to cisplatin-induced apoptosis in CxCa cells, highlighting the need for further investigation into viral oncoprotein interactions to overcome therapeutic resistance.
Authors
- Seyed Masoud Hosseini (ORCID: https://orcid.org/0000-0002-8906-5833)
- Fatemeh Pakdel (ORCID: https://orcid.org/0000-0001-7119-5042)
- Ali Farhadi (ORCID: https://orcid.org/0000-0002-2271-670X)
- Neda Soleimani (ORCID: https://orcid.org/0000-0003-0803-9818)
Institutions
- Shiraz University of Medical Sciences (IR)
- Shahid Beheshti University (IR)
Publication Details
- Journal
- Advanced Pharmaceutical Bulletin
- Published
- 2025-03-09
- DOI
- https://doi.org/10.34172/apb.43882
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shiraz University of Medical Sciences
- Shiraz University