Perfluorooctanoic acid serum concentrations and half-lives in a community exposed to contaminated drinking water in New York State

This biomonitoring project assisted communities with PFOA-contaminated drinking water by providing comparative exposure information and tracking body burden reductions to confirm exposures were minimized. These data are also critical for filling gaps in knowledge about PFOA modes of action and for the conduct of studies that can identify exposure concentrations associated with health risks. The detailed PFOA serum findings described here are being used to construct and validate pharmacokinetic models that will estimate exposures over the lifespan. These findings provide a foundation for PFOA exposure assessment that will benefit the national Multi-Site PFAS Health Study and future studies as well.