Impact of spinal anesthesia on myocardial damage, ultrastructure and cellular mechanisms in rats undergoing thoracic incision surgery
Surgery can cause ultrastructural and cellular damage, elevate sympathetic activity, oxidative stress, and endoplasmic reticulum stress, leading to autophagy and cardiomyocyte apoptosis. Spinal anesthesia can protect the heart from these injuries.
Authors
- Wen-Lieng Lee (ORCID: https://orcid.org/0000-0003-1956-7122)
- Vanita Shih
- Li-Chuan Wang
- Hui‐Chin Lai (ORCID: https://orcid.org/0000-0002-0077-9881)
- Yueh‐Chiao Yeh (ORCID: https://orcid.org/0000-0002-6488-7144)
- Tsun-Jui Liu
Institutions
- National Yang Ming Chiao Tung University (TW)
- Taichung Veterans General Hospital (TW)
- Nanhua University (TW)
- University of Rochester (US)
Publication Details
- Journal
- Toxicology and Applied Pharmacology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.taap.2025.117349
- Citations
- 2
- Primary Topic
- Cardiac, Anesthesia and Surgical Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Ministry of Science and Technology, Taiwan
- Taichung Veterans General Hospital