Factors Contributing to Non-Alcoholic Fatty Liver Disease and Glycogen Storage in Type 1 Diabetes Mellitus

Factors that may contribute to the development of fatty liver in T1DM include: acquired hepatic and peripheral insulin resistance, hyperglycemia-induced activation and dysregulation of transcription factors that regulate intrahepatic lipid processing, altered insulin delivery to the liver, lipoprotein abnormalities. Interactions and exposures are bidirectional between NAFLD and insulin resistance in type 1 diabetes mellitus. Hepatic steatosis in T1DM patients may be due to hepatic glycogenosis and indirectly by increased free fatty acid flow to the liver through reduced peripheral inhibition of lipolysis.