Atrial fibrillation is associated with higher oxygen extraction in the human heart
AF significantly affects myocardial oxygen utilization by reducing both myocardial blood flow and cardiac power, thereby requiring increased oxygen extraction. This 2-hit mechanism-reduced supply and increased demand-highlights the symptomatic challenges in managing AF and emphasizes the need for therapeutic strategies to optimize cardiac physiology in these patients.
Authors
- Nona Sotoodehnia (ORCID: https://orcid.org/0000-0002-2705-6237)
- NAZEM W. AKOUM (ORCID: https://orcid.org/0000-0002-2001-6806)
- Karen Ordovás (ORCID: https://orcid.org/0000-0001-5438-4669)
- Nadia Chamoun (ORCID: https://orcid.org/0000-0002-6623-8260)
- Rong Tian (ORCID: https://orcid.org/0000-0002-3676-3830)
- Romanos Haykal
- Dennis Wang (ORCID: https://orcid.org/0000-0003-0068-1005)
- Yaacoub Chahine (ORCID: https://orcid.org/0000-0002-2752-220X)
- Ahmad Kassar (ORCID: https://orcid.org/0009-0006-1082-8858)
- Jason Li (ORCID: https://orcid.org/0000-0002-1150-3549)
- Lee Bockus (ORCID: https://orcid.org/0000-0001-5398-6254)
- Kevin O'BrienMD
Institutions
- University of Washington (US)
Publication Details
- Journal
- American Heart Journal
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.ahj.2025.04.013
- Citations
- 2
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.78