The presumable combined effects of hydroxychloroquine and its metabolites on the blood lipids and glucose in the treatment of rheumatoid arthritis
HCQ might increase HDL level and reduce LDL, VLDL, TC, and TG levels in RA treatment. These beneficial effects on modifying lipid profile might be counteracted to various degrees by some of its metabolites (DHCQ and BDCQ). Therefore, for RA patients with HCQ in their treatment regime, it might facilitate the improvement of lipids profile by promoting the excretion of HCQ metabolites. This study did not demonstrate the significant hypoglycemic effect of HCQ and its metabolites.
Authors
- Xueting Wu (ORCID: https://orcid.org/0009-0001-1233-955X)
- Zhi Yang (ORCID: https://orcid.org/0000-0002-1060-5586)
- Hanxin Zhang (ORCID: https://orcid.org/0000-0001-5069-634X)
- Zongwen Shuai (ORCID: https://orcid.org/0000-0002-5708-6509)
- Yaqian Dai (ORCID: https://orcid.org/0000-0002-8049-0796)
- Yue Wang (ORCID: https://orcid.org/0000-0001-8673-6358)
Institutions
- Anhui University (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Inflammopharmacology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1007/s10787-025-01735-9
- Citations
- 1
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- Anhui Medical University