Phytosomes: An Ideal way to Enhance Bioavailability of Mangiferin

Today, one of the most challenging public health issues is diabetes mellitus. Despite the availability of therapeutic medications, they exhibit several limitations. Given the escalating prevalence and fatality rates, there is a pressing need for more potent therapeutic drugs in clinical treatment. Mangiferin, a polyphenol and natural substance, offers a wide array of beneficial pharmacological properties. However, its applicability in research and clinical settings is hampered by its membership in the BCS class IV due to weak water solubility, poor fat solubility, and low bioavailability. Addressing these limitations is crucial. Our comprehensive review delves into strategies for enhancing mangiferin's solubility by modifying its dosage form. Additionally, we highlight preliminary findings, aiming to provide a valuable roadmap for the future application of mangiferin in diabetes management. It is conceivable that in the near future, mangiferin could serve as an adjuvant medication for diabetes mellitus treatment and its associated complications.