S-Adenosylmethionine Inhibits Plasminogen-Activating Inhibitor-1 and Protects Male Mice From FOLFOX-Induced Liver Injury
FOLFOX treatment increased hepatocyte PAI-1 expression and liver injury, which were not observed in germline PAI-1 deficiency. Hepatocytes secrete PAI-1 to exert autocrine and paracrine effects to activate Kupffer cells and liver sinusoidal endothelial cells. SAMe protects against FOLFOX-mediated liver injury in part by inhibiting NF-κB activation and PAI-1 induction.
Authors
- Shelly Chi-Loo Lu (ORCID: https://orcid.org/0000-0003-2128-5407)
- Andrea Floris (ORCID: https://orcid.org/0000-0002-3160-6676)
- Maria Lauda Tomasi (ORCID: https://orcid.org/0000-0001-8156-9052)
- Alexandra Gangi (ORCID: https://orcid.org/0000-0002-9512-7973)
- Swati Chandla
- Arash Khangholi
- Tony W. Li
- Youngyi Lim (ORCID: https://orcid.org/0000-0002-5609-8356)
Institutions
- Cedars-Sinai Medical Center (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101513
- Citations
- 2
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- U.S. Department of Defense
- National Institutes of Health