A Cross Sectional and Longitudinal Assessment of Neuropsychiatric Symptoms and Brain Functional Connectivity in Patients With Mild Cognitive Impairment, Cerebrovascular Disease and Parkinson Disease
In conclusion, our study highlights the critical role of the DMN, ECN, and SN in processing neuropsychiatric symptoms (NPS) across MCI, CVD, and PD populations. We found significant associations between NPS and functional connectivity (FC) within and between these networks. MCI and PD showed positive associations with FC, particularly for disturbed nighttime behavior, while CVD exhibited negative associations, notably with anxiety and agitation. Although irritability was common in both MCI and CVD groups, its neural correlates remain unclear, emphasizing the need for further investigation. These findings support existing literature and pave the way for targeted therapeutic approaches, such as brain stimulation, to alleviate NPS. Additionally, the complex role of CNS medications in modulating NPS and FC warrants further investigation.
Authors
- Anthony E. Lang (ORCID: https://orcid.org/0000-0003-1229-3667)
- Bruce G. Pollock (ORCID: https://orcid.org/0000-0003-0802-3998)
- Morris Freedman (ORCID: https://orcid.org/0000-0003-4003-6158)
- David F. Tang‐Wai (ORCID: https://orcid.org/0000-0001-9747-9967)
- Zahinoor Ismail (ORCID: https://orcid.org/0000-0002-5529-3731)
- Dallas Seitz (ORCID: https://orcid.org/0000-0003-1274-6451)
- Stephen Pasternak (ORCID: https://orcid.org/0000-0002-0204-0255)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- Neda Rashidi‐Ranjbar (ORCID: https://orcid.org/0000-0002-2125-1090)
- Corinne E. Fischer (ORCID: https://orcid.org/0000-0002-1047-0167)
- Paula McLaughlin (ORCID: https://orcid.org/0000-0001-7173-8449)
- Nathan W. Churchill (ORCID: https://orcid.org/0000-0001-8481-2505)
- Tom A. Schweizer (ORCID: https://orcid.org/0000-0003-2278-3539)
- Sandra E. Black (ORCID: https://orcid.org/0000-0001-7093-8289)
- Dar Dowlatshahi (ORCID: https://orcid.org/0000-0003-1379-3612)
- Sean Symons (ORCID: https://orcid.org/0000-0002-8025-9965)
- Joel Ramı́rez-Emiliano (ORCID: https://orcid.org/0000-0001-9813-9120)
- Andrew Frank (ORCID: https://orcid.org/0009-0002-8587-7727)
- Tarek K. Rajji (ORCID: https://orcid.org/0000-0002-8324-2560)
- Gustavo Saposnik (ORCID: https://orcid.org/0000-0002-5950-9886)
- Michael Borrie
- Luis Fornazzari
- Christopher J.M. Scott (ORCID: https://orcid.org/0000-0002-3236-7523)
- Ayman Hassan (ORCID: https://orcid.org/0000-0002-7562-2002)
- David G. Munoz (ORCID: https://orcid.org/0000-0001-6027-8870)
- Sanjeev Kumar
- Mario Masellis
Institutions
- St. Michael's Hospital (CA)
- Dalhousie University (CA)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- Centre for Addiction and Mental Health (CA)
- University of Ottawa (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- Ottawa Hospital (CA)
- London Health Sciences Centre (CA)
- Health Sciences Centre (CA)
- Nova Scotia Health Authority (CA)
- Baycrest Hospital (CA)
- St Joseph's Health Centre (CA)
- Thunder Bay Regional Research Institute (CA)
- Occupational Cancer Research Centre (CA)
- Bruyère (CA)
- Ottawa Hospital Research Institute (CA)
- NOSM University (CA)
Publication Details
- Journal
- International Journal of Geriatric Psychiatry
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/gps.70075
- Citations
- 5
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.16
Funders
- University of Ottawa
- McMaster University
- London Health Sciences Foundation
- Queen's University
- Temerty Family Foundation
- Faculty of Health Sciences, Queen's University