Elevated Cholinesterase Activity and the Metabolic Syndrome—Dissecting Fatty Liver, Insulin Resistance and Dysglycaemia
Higher plasma BChE activity is linked to liver fat accumulation, as well as impaired glucose tolerance and insulin resistance, independent of liver fat. This suggests that BChE could be a marker for processes in hepatocytes that contribute to impaired glucose metabolism. Further investigations are needed to clarify the mechanistic contribution and potential diagnostic value of elevated BChE in hepatic steatosis and metabolic diseases.
Authors
- Norbert Stefan (ORCID: https://orcid.org/0000-0002-2186-9595)
- Martin Heni (ORCID: https://orcid.org/0000-0002-8462-3832)
- Alfred Königsrainer (ORCID: https://orcid.org/0000-0002-2301-4080)
- Julia Hummel (ORCID: https://orcid.org/0000-0002-9724-8365)
- Louise Fritsche (ORCID: https://orcid.org/0000-0003-0644-6161)
- Andreas L. Birkenfeld (ORCID: https://orcid.org/0000-0003-1407-9023)
- Jürgen Machann (ORCID: https://orcid.org/0000-0002-4458-5886)
- Andreas Peter (ORCID: https://orcid.org/0000-0001-5732-2287)
- Robert Wagner (ORCID: https://orcid.org/0000-0003-4634-3757)
- Fritz Schick (ORCID: https://orcid.org/0000-0002-4231-3406)
- Lasse Relker
- Andreas Fritsche (ORCID: https://orcid.org/0000-0002-4987-1961)
- Hans‐Ulrich Häring (ORCID: https://orcid.org/0000-0003-4655-9937)
- Erwin Schleicher (ORCID: https://orcid.org/0000-0003-3565-3733)
Institutions
- Universität Ulm (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Liver International
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1111/liv.70046
- Citations
- 4
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Eberhard Karls Universität Tübingen
- Bundesministerium für Bildung und Forschung