Genomic insights and phenotypic characterization of three multidrug resistant <i>Cupriavidus</i> strains from the cystic fibrosis lung
Our Cupriavidus spp. isolates showed considerable genomic and phenotypic variability that may impact their virulence and treatment in PWCF, where multidrug resistance will negate treatments and biofilm formation and motility play key roles in infection establishment, as seen in CF pathogens like Pseudomonas aeruginosa. More detailed investigation of clinical Cupriavidus isolates is needed for full understanding of the risk they pose to PWCF.
Authors
- Sean D. Kelly (ORCID: https://orcid.org/0000-0001-8004-5951)
- D. Kenna (ORCID: https://orcid.org/0000-0002-3105-3637)
- Mathew Upton (ORCID: https://orcid.org/0000-0003-4287-6396)
- Vicky Bennett
- Sumita Pai
- Katie J. Muddiman (ORCID: https://orcid.org/0000-0002-0396-6893)
- György Fejér
- Heather Green (ORCID: https://orcid.org/0000-0003-4254-4076)
- Andrew Jones (ORCID: https://orcid.org/0000-0003-3232-1055)
- James A. Butler
- Trudie A McComb
- Briana M Barrand
Institutions
- University of Exeter (GB)
- Public Health England (GB)
- Manchester University NHS Foundation Trust (GB)
- Papworth Hospital NHS Foundation Trust (GB)
- Wythenshawe Hospital (GB)
- University of Bath (GB)
- University of Plymouth (GB)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1093/jambio/lxaf093
- Citations
- 1
- Primary Topic
- Infections and bacterial resistance
- Type
- article
- Field-Weighted Citation Impact
- 1.80
Funders
- Boomer Esiason Foundation
- Medical Research Council