Copper-Catalyzed Reductive Hydroamination of Inactive Diarylacetylenes with Nitroarenes
Reductive hydroamination of stable and readily available nitroarenes with unsaturated hydrocarbons represents practical access to amines. Herein, we report a simple Cu-catalyzed amine synthesis via the reductive hydroamination of nitroarenes with inactive diarylacetylenes. A series of diarylacetylenes are successfully transformed into secondary amines under mild conditions with good functional group tolerance.
Authors
- Mengjie Cen
- Zhiyou Li (ORCID: https://orcid.org/0000-0002-2989-4568)
- Tianzeng Huang (ORCID: https://orcid.org/0000-0002-1568-0817)
- Tieqiao Chen (ORCID: https://orcid.org/0000-0002-9787-9538)
- Long Liu (ORCID: https://orcid.org/0000-0002-6472-5057)
- Qiang Li (ORCID: https://orcid.org/0000-0002-8687-0773)
- Xinyue Ma (ORCID: https://orcid.org/0000-0003-3463-9809)
- Chunya Li (ORCID: https://orcid.org/0000-0002-4252-1002)
- Jie Tang
Institutions
- Liaocheng University (CN)
- Hainan University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1021/acs.orglett.5c00964
- Citations
- 1
- Primary Topic
- Nanomaterials for catalytic reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hainan Province
- Hainan University
- Key Research and Development Project of Hainan Province