Gliadin-dependent UPR induction directly triggers the expression of TG2 and pro-inflammatory cytokines, dysregulates intestinal permeability, and reduces CFTR expression in intestinal epithelial cells of celiac disease patients
Overall, our analysis has highlighted the key role of ER stress in the pathogenesis of CD and identified the chemical chaperones as a new potential valuable therapeutic treatment for CD patients.
Authors
- Mara Gagliardi (ORCID: https://orcid.org/0000-0002-3222-790X)
- Ivana Rabbone (ORCID: https://orcid.org/0000-0003-4173-146X)
- Alice Monzani (ORCID: https://orcid.org/0000-0002-6676-5773)
- Marco Corazzari (ORCID: https://orcid.org/0000-0002-6246-5968)
- Valentina Saverio (ORCID: https://orcid.org/0000-0002-1770-2661)
- Romina Monzani (ORCID: https://orcid.org/0000-0001-9750-8342)
- Silvia Saettone
- Daniele Sblattero (ORCID: https://orcid.org/0000-0003-4309-242X)
- Luigina De Leo (ORCID: https://orcid.org/0000-0003-4013-1630)
- Nausicaa Clemente (ORCID: https://orcid.org/0000-0002-9860-0148)
- Nico Pagano (ORCID: https://orcid.org/0000-0002-0626-4563)
- Dmitry Lim (ORCID: https://orcid.org/0000-0002-4316-2654)
- Francesca Nigrelli
- Emanuele Ferrario
- Samuele Pellizzaro
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University of Trieste (IT)
- IRCCS Materno Infantile Burlo Garofolo (IT)
- Azienda Ospedaliero Universitaria Maggiore della Carita (IT)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s13062-025-00644-9
- Citations
- 2
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.62
Funders
- Dipartimenti di Eccellenza
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Horizon 2020 Framework Programme