Direct screening and quantification of monoclonal immunoglobulins in serum using MALDI-TOF mass spectrometry without antibody enrichment
The iMS-LC Assay shows potential to replace SPE and drive advancements in the screening, diagnosis, and monitoring of MGs. Further validation of its clinical sensitivity and specificity is essential to determine its adequacy as a routine screening tool for M-proteins.
Authors
- Peng Ye (ORCID: https://orcid.org/0000-0003-2676-647X)
- Ling Ji (ORCID: https://orcid.org/0000-0003-4088-2514)
- Shang Ying Wu (ORCID: https://orcid.org/0000-0002-5683-7710)
- Hui Yu (ORCID: https://orcid.org/0000-0002-5605-0950)
- Bingqing Cao
- Anping Xu (ORCID: https://orcid.org/0000-0002-9827-7272)
- Huan Ding (ORCID: https://orcid.org/0000-0001-5046-2236)
- Yueying Huang
- Hou‐Long Luo (ORCID: https://orcid.org/0000-0001-6559-4012)
- Yuxi Wang (ORCID: https://orcid.org/0000-0002-6884-829X)
- Rong He (ORCID: https://orcid.org/0000-0001-5779-951X)
- Liansheng Wang (ORCID: https://orcid.org/0000-0001-8070-5171)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Peking University Shenzhen Hospital (CN)
- Shanghai Industrial Technology Institute (CN)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1515/cclm-2025-0203
- Citations
- 2
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.54