Abstract P1027: Associations between sleep quality and individual lipid abnormalities in Hong Kong Chinese women: Findings from the MECH-HK study

Background: Many studies on the relationship between sleep quality and dyslipidemia have been conducted, but the findings have been inconsistent. Dyslipidemia refers to the presence of one or more of individual lipid conditions: high total cholesterol (TC) level, high triglycerides (TG) level, high low-density lipoprotein cholesterol (LDL-C) level, and low high-density lipoprotein cholesterol (HDL-C) level. Few studies have investigated the relationships between sleep and individual lipid components in Chinese population. Identifying the specific lipid components associated with sleep might help target prevention and improving precise management of dyslipidemia. Methods: Baseline data (collected between October 2019 - December 2020) of the Migraine Exposures and Cardiovascular Health in Hong Kong Chinese women (MECH-HK) cohort were used for analyses. Sleep quality was measured by the Chinese version of the Pittsburgh Sleep Quality Index (PSQI). It has an overall score and 7 domains. Poor sleep quality was defined as overall score > 5. Blood lipids in terms of TC, TG, LDL-C, and HDL-C were measured by CardioChek PA device, and categorized as normal or abnormal according to the Chinese guidelines for lipid management (2023). Results: A total of 3531 adult women were included. The prevalence of poor sleep quality, abnormal TC, TG, LDL-C, and HDL-C was 64.7%, 12.9%, 21.7%, 4.8%, and 3.4% respectively. The association between sleep quality and dyslipidemia was not significant. As for individual lipid abnormalities, poor sleep quality was only associated with 3.0% greater odds of abnormal LDL-C (95% CI: 0.5~5.5%). Regarding sleep pattern, sleep duration ( OR =1.018, 95% CI : 1.006~1.030) and sleep disturbances ( OR =1.033, 95% CI : 1.012~1.055) were associated with abnormal LDL-C. Sleep duration ( OR =1.021, 95% CI : 1.008~1.034) and sleep disturbances ( OR =1.027, 95% CI : 1.005~1.050) were also associated with abnormal TC, while sleep latency ( OR =1.007, 95% CI = 1.001~1.014) and sleep efficiency ( OR =1.005, 95% CI : 1.001~1.009) were associated with abnormal HDL-C. No significant associations were observed between any of the sleep components and abnormal TG. Conclusion: The association of poor sleep quality with dyslipidemia appeared mainly between sleep and abnormal LDL-C. Different sleep patterns were linked to specific lipid components, suggesting that future research may focus on tailored management strategies based on specific sleep patterns and types of dyslipidemia.