Depression reduces cognitive function partly through effects on BMI and hypertension: a large observational study and Mendelian randomization analysis
Our study indicates that depression can lead to obesity and hypertension, which can reduce cognitive function. These findings underscore the importance of timely identification and management of depression in patients with cognitive impairments and suggest that treatments aimed at reducing weight and lowering blood pressure may help prevent cognitive impairment.
Authors
- Yanxin Wang (ORCID: https://orcid.org/0000-0002-4105-7172)
- Zhao Wang (ORCID: https://orcid.org/0000-0003-2493-7538)
- Yanyan Chen (ORCID: https://orcid.org/0000-0001-5268-5265)
- Hongyang Gong
- Taotao Mi
Institutions
- Tongji University (CN)
- Chosun University (KR)
- Chungnam National University (KR)
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s12888-025-06846-9
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Chosun University