Abstract P1176: The Association of Urinary Incontinence, Physical Activity, and Cardiovascular Disease Risk in Women

Introduction: Urinary incontinence (UI) is a common condition among women. Emerging evidence indicates UI might contribute to lower physical activity (PA) levels. Thus, women with UI may have increased risk for inactivity and related cardiovascular disease (CVD). Hypothesis: Women with UI, compared to women without UI, will 1) have higher odds of being inactive or insufficiently active, and 2) have higher odds of cardiovascular risk factors or diagnosed cardiovascular disease. Methods: This retrospective observational study used electronic medical records to capture data on UI diagnosis, self-reported moderate-to-vigorous PA using the Exercise Vital Sign, Atherosclerotic Cardiovascular Disease (ASCVD) risk factor components and the diagnosis or management of CVD using ICD-10 codes, and demographic information. Multinomial logistic regression assessed the association of UI and PA classification (inactive: 0 min/week, insufficiently active: 1-149 min/week, and active ≥150 min/week). Multiple variable logistic regression models assessed associations of UI with CVD risk calculator components and diagnosed CVD. All models adjusted for age, race, body mass index, and tobacco use. Results: Of 20,155 women who were included in analysis (mean age 50.36±16.42 years), 1,085 (5.4%) had a UI diagnosis. Women with UI were on average 11.4 years older than those without UI. A greater proportion of those with UI were current or former smokers compared to those without UI. Activity classification did not differ in those with and without UI. Those with UI had greater odds of type 2 diabetes (aOR 1.25, 95% CI: 1.06-1.48), dyslipidemia (aOR 1.37, 95% CI: 1.19-1.58), stroke (aOR 1.55, 95% CI: 1.06-2.25), and coronary artery bypass grafts (aOR 3.17, 95% CI: 1.45-6.95) than those without UI (Table 1). Conclusions: UI was not associated with PA classification; future studies should investigate whether increasing PA among women with UI can mitigate associations of UI and CVD risk. Women with UI also present with risk factors for CVD and the association should be further studied. Additionally, women with CVD should be screened for UI.