Causal role of MiRNAs in chronic rhinosinusitis: mendelian randomization and validation study
MiR-130a-3p and miR-196b-5p are positively associated with CRS risk, whereas miR-339-3p is protective. These miRNAs represent promising diagnostic biomarkers and therapeutic targets for CRS. The MAPK and PI3K-AKT pathways likely mediate the effects of these causal miRNAs, offering further insight into the molecular mechanisms underlying CRS.
Authors
- Zhixuan Ma
- Lei Shi (ORCID: https://orcid.org/0000-0002-4976-2159)
- Yiran Zhao (ORCID: https://orcid.org/0009-0003-9675-3233)
- Fu Shu (ORCID: https://orcid.org/0000-0002-3014-5038)
Institutions
- Hong Kong Baptist University (HK)
- Liaoning University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Allergy Asthma and Clinical Immunology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s13223-025-00957-4
- Citations
- 1
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- State Administration of Traditional Chinese Medicine of the People's Republic of China