Drp1 mitochondrial fission in astrocyte modulates behavior and neuroinflammation during morphine addiction
Collectively, our findings suggest that alterations in mitochondrial dynamics, particularly within astrocytes, play an important role in regulating neuroinflammation associated with morphine addiction. This research offers novel insights into potential therapeutic strategies for addressing substance use disorder (SUD) by regulating mitochondrial dynamics within astrocyte.
Authors
- Feifan Zhou (ORCID: https://orcid.org/0000-0001-8213-507X)
- Qi Su (ORCID: https://orcid.org/0000-0002-6490-686X)
- Wenjing Chen (ORCID: https://orcid.org/0000-0002-1638-6206)
- Xinran Wang (ORCID: https://orcid.org/0000-0002-3975-1667)
- Zixin Li (ORCID: https://orcid.org/0009-0005-3425-5727)
- Xiaotong Gu
Institutions
- Hainan University (CN)
- State Key Laboratory of Digital Medical Engineering (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s12974-025-03438-y
- Citations
- 9
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 6.45