Cover Feature: The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit to Lead (ChemMedChem 8/2025)
“Searching for diamonds in the rough” summarises consensus best practices in how to expedite the processes and enable decision making in the Hits-to-Leads phase of drug discovery. The EFMC Best Practices Group, led by Jean Quancard, draws on expertise from seasoned drug hunters (industrial and academic) from all over Europe, producing open-source educational materials. This paper complements webinars on the topic, part of an expanding series with associated online content (videos of presentations, slides, publications) produced to be open-source educational materials. More details can be found in article 10.1002/cmdc.202400931 by Jean Quancard, Robert J. Young, and co-workers.
Authors
- Ingo V. Hartung (ORCID: https://orcid.org/0000-0001-8750-679X)
- Russell Craft (ORCID: https://orcid.org/0000-0002-5108-2312)
- Hannes F. Koolman
- Gianluca Sbardella (ORCID: https://orcid.org/0000-0003-0748-1145)
- Jean Quancard (ORCID: https://orcid.org/0000-0001-6324-8490)
- Josef Messinger (ORCID: https://orcid.org/0000-0001-7920-0571)
- Stefan Laufer (ORCID: https://orcid.org/0000-0001-6952-1486)
- Susan Lepri (ORCID: https://orcid.org/0000-0003-1024-7368)
- Chiara Borsari (ORCID: https://orcid.org/0000-0002-4688-8362)
- Stéphanie M. Guéret (ORCID: https://orcid.org/0000-0001-7220-9506)
- Robert J. Young (ORCID: https://orcid.org/0000-0002-7763-0575)
- Marina K. Willwacher (ORCID: https://orcid.org/0000-0001-9119-7539)
- Anders Bach (ORCID: https://orcid.org/0000-0003-4305-9910)
- Kurt Ritter
- Brian J. Cox (ORCID: https://orcid.org/0000-0002-5980-9707)
- Andrea Unzue Lopez
- Christian Gnamm (ORCID: https://orcid.org/0000-0001-7392-9513)
Institutions
- University of Copenhagen (DK)
- Novartis (Switzerland) (CH)
- University of Salerno (IT)
- Boehringer Ingelheim (Germany) (DE)
- University of Sussex (GB)
- Merck KGaA, Darmstadt (Germany) (DE)
- University of Milan (IT)
- Flevoziekenhuis (NL)
- Orion Corporation (Finland) (FI)
- AstraZeneca (Sweden) (SE)
- University of Tübingen (DE)
Publication Details
- Journal
- ChemMedChem
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1002/cmdc.202580804
- Primary Topic
- Science, Research, and Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00