Pleural fluid proteomics from patients with pleural infection shows signatures of diverse neutrophilic responses: The Oxford Pleural Infection Endotyping Study (TORPIDS-2)
These findings suggest that pleural infection patients exhibit diverse responses of neutrophil-mediated immunity, glycolysis and pentose phosphate activation, which are associated with microbiology. Therapeutic targeting of the liver and retinoid X receptors pathway with agonists is a possible treatment approach.
Authors
- G. Berridge
- Nikolaos I. Kanellakis (ORCID: https://orcid.org/0000-0002-0065-2282)
- Román Fischer (ORCID: https://orcid.org/0000-0002-9715-5951)
- Tao Dong (ORCID: https://orcid.org/0000-0003-3557-1850)
- Iolanda Vendrell (ORCID: https://orcid.org/0000-0001-7187-4061)
- Elie Antoun (ORCID: https://orcid.org/0000-0002-9477-1564)
- Zheqing Zhang (ORCID: https://orcid.org/0000-0001-8386-0361)
- Julian Charles Knight (ORCID: https://orcid.org/0000-0002-0377-5536)
- Najib Mahboob Rahman (ORCID: https://orcid.org/0000-0003-1195-1680)
- Justin P. Whalley (ORCID: https://orcid.org/0000-0002-0403-3091)
- Nikita Manoharan
- Alguili Elsheikh (ORCID: https://orcid.org/0009-0002-9965-0240)
- Julia Chu (ORCID: https://orcid.org/0009-0000-2710-7244)
- John P. Corcoran (ORCID: https://orcid.org/0000-0002-0480-7819)
- Kiki Cano-Gamez (ORCID: https://orcid.org/0000-0003-2753-1226)
Institutions
- Centre for Human Genetics (GB)
- Rosalind Franklin University of Medicine and Science (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Angkor Hospital for Children (KH)
- Churchill Hospital (GB)
- National Institute for Health and Care Research (GB)
- University of Oxford (GB)
- MRC Human Immunology Unit (GB)
- Science Oxford (GB)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1183/13993003.00010-2025
- Citations
- 2
- Primary Topic
- Amoebic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- John Fell Fund, University of Oxford
- Chinese Academy of Medical Sciences Initiative for Innovative Medicine