CD5 and p53 immunohistochemistry: valuable prediction method in molecular typing of CD5-positive diffuse large B-cell lymphoma
For CD5 strong positive cases, a wild pattern of p53 likely indicates MCD subtype, while a mutant p53 pattern may suggest TP53<sup>Mut</sup> subtype. CD5 and p53 may potentially offer initial molecular subtyping for CD5-positive DLBCLs. We suggest incorporating these two markers into the routine pathological diagnosis of DLBCL to assist in guiding preliminary classification and influencing treatment decisions.
Authors
- Xiu Nie (ORCID: https://orcid.org/0000-0002-5958-1650)
- Tao Liu (ORCID: https://orcid.org/0000-0001-8735-0115)
- Danju Luo
- Liangliang Shi (ORCID: https://orcid.org/0000-0001-5039-5643)
- Jun Fan (ORCID: https://orcid.org/0000-0002-1433-7283)
- Xiaona Chang
- Xinyi Li (ORCID: https://orcid.org/0000-0002-3558-3977)
- Han Wang (ORCID: https://orcid.org/0000-0002-7475-1830)
- Liling Zhang (ORCID: https://orcid.org/0000-0002-0198-2603)
- Beibei Gao (ORCID: https://orcid.org/0000-0003-0288-0702)
- Qiuhui Li (ORCID: https://orcid.org/0000-0003-0837-0893)
- Huaxiong Pan
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s12885-025-13990-8
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00