Chemical constituents and anti-inflammatory investigation of Elsholtzia rugulosa Hemsl
Two undescribed furan derivatives elsholtzia ketone-9-O-β-glucopyranoside (1) and 8-hydroxy-elsholtzia ketone-9-O-β-glucopyranoside (2) along with ten known compounds (3-12), were isolated from Elsholtzia rugulosa Hemsl. Their structures were elucidated based on extensive analyses of spectroscopic data and quantum chemical calculations. Anti-inflammatory experiments showed that 1, 7, and 12 reduce the production of nitric oxide (NO) and the levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) induced by lipopolysaccharide (LPS) in RAW264.7 cells.
Authors
- Qiong Jin (ORCID: https://orcid.org/0000-0001-9882-5278)
- Zhu‐Ya Yang (ORCID: https://orcid.org/0000-0002-3427-5200)
- Peifen Zhu (ORCID: https://orcid.org/0000-0002-5269-541X)
- Xin Duan (ORCID: https://orcid.org/0000-0003-1685-1021)
- Jiamei Geng
- Lu Liu (ORCID: https://orcid.org/0000-0003-4865-1673)
- Xue-Ying Xu
Institutions
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Fitoterapia
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.fitote.2025.106550
- Citations
- 1
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 1.23
Funders
- Major Scientific and Technological Special Project of Guizhou Province