Dietary associations with reduced epigenetic age: a secondary data analysis of the methylation diet and lifestyle study
In hierarchical linear regression, foods investigated as polyphenolic modulators of DNA methylation (green tea, oolong tea, turmeric, rosemary, garlic, berries) categorized in the original study as methyl adaptogens showed significant linear associations with epigenetic age change (B = -1.24, CI = [-2.80, -0.87]), after controlling for baseline epigenetic age acceleration and weight changes. Although the intervention group lost significantly more weight than the control group, these changes were not associated with epigenetic age changes in the regression model. These findings suggest that consuming foods categorized as methyl adaptogens may reduce markers of epigenetic aging.
Authors
- Alexandra Adorno Vita (ORCID: https://orcid.org/0000-0001-5126-0601)
- J.J. Villanueva (ORCID: https://orcid.org/0000-0002-5713-497X)
- Benjamin Zimmerman (ORCID: https://orcid.org/0000-0003-2570-8198)
- Heather Zwickey (ORCID: https://orcid.org/0000-0002-1600-401X)
- Kara Fitzgerald (ORCID: https://orcid.org/0000-0003-4062-3790)
- Ryan Bradley (ORCID: https://orcid.org/0000-0002-8073-3671)
- Romilly Hodges (ORCID: https://orcid.org/0000-0001-6225-5664)
Institutions
- National University of Natural Medicine (US)
- University of Washington (US)
- University of California San Diego (US)
- Human Longevity (United States) (US)
- Sonoran Biosciences (United States) (US)
- Institute for Molecular Medicine (US)
- Colorado State University (US)
Publication Details
- Journal
- Aging
- Published
- 2025-04-17
- DOI
- https://doi.org/10.18632/aging.206240
- Citations
- 7
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Center for Complementary and Integrative Health