The role of factor V in trauma-induced coagulopathy: an observational and experimental study
FV depletion after trauma is associated with increased mortality. In an <i>in vitro</i> model of TIC, FV(a) results in procoagulant, antifibrinolytic, and anticoagulant effects. Further research is highly warranted.
Authors
- Pieter H. Sloos
- Marc Maegele (ORCID: https://orcid.org/0000-0002-0634-4723)
- Pär I. Johansson (ORCID: https://orcid.org/0000-0001-9778-5964)
- Romein W. G. Dujardin (ORCID: https://orcid.org/0000-0003-1095-3502)
- Simon Stanworth (ORCID: https://orcid.org/0000-0002-7414-4950)
- Jakob Stensballe (ORCID: https://orcid.org/0000-0002-2351-9273)
- Joost C.M. Meijers (ORCID: https://orcid.org/0000-0002-4198-6780)
- Derek J. B. Kleinveld (ORCID: https://orcid.org/0000-0002-6357-1471)
- Ross Davenport (ORCID: https://orcid.org/0000-0002-8593-6582)
- Christine Gaarder (ORCID: https://orcid.org/0000-0002-9485-1783)
- Nicole P. Juffermans (ORCID: https://orcid.org/0000-0002-3039-6574)
Institutions
- Oslo University Hospital (NO)
- NHS Blood and Transplant (GB)
- Witten/Herdecke University (DE)
- Queen Mary University of London (GB)
- Barts Health NHS Trust (GB)
- Erasmus MC (NL)
- Copenhagen University Hospital (DK)
- Amsterdam University Medical Centers (NL)
- Institute of Infection and Immunity (CA)
- University of Amsterdam (NL)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.rpth.2025.102857
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Octapharma