Selective Mapping of Brain COX-1 with [11C]PS13: Pharmacokinetic Evidence from human PET Imaging
Ketoprofen demonstrated the highest selectivity for COX-1, while celecoxib exhibited partial occupancy likely due to dose- or time-dependent COX-1 inhibition. Aspirin showed minimal effect. Given the small sample size (n = 8), further studies with larger cohorts are warranted to confirm these findings and assess pharmacokinetic influences more thoroughly.
Authors
- Maryam T. Fazel (ORCID: https://orcid.org/0000-0002-5383-1997)
- Mahsa Asadi Anar (ORCID: https://orcid.org/0000-0002-5772-2472)
- Sahar Mesbah
- Shahid Zaman (ORCID: https://orcid.org/0000-0003-1639-6014)
- Mehrnaz Salahi
- Reza Hossein Zadeh
- Niloofar Deravi
- Alaleh Alizadeh
- Sajjad Hajihosseini
- Kiana Orangi
- Kimiya Batebi
- Farnoosh Vosough
- Mahdiyeh Nozad Varjovi
- Fatemeh Salehian
Institutions
- Isfahan University of Medical Sciences (IR)
- Ahvaz Jundishapur University of Medical Sciences (IR)
- University of Arizona (US)
- Iran University of Medical Sciences (IR)
- Tabriz University of Medical Sciences (IR)
- Mashhad University of Medical Sciences (IR)
- Islamic Azad University, Mashhad (IR)
- Shahid Sadoughi University of Medical Sciences and Health Services (IR)
- Islamic Azad University Medical Branch of Tehran (IR)
- Islamic Azad University Pharmaceutical Sciences Branch (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.ibneur.2025.04.012
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00