Magnesium-based implants accelerate femoral fracture healing through promoting histone lactylation-mediated osteoclastogenesis inhibition
This study uncovers a novel mechanism by which Mg<sup>2+</sup> promotes fracture healing through histone lactylation-mediated inhibition of osteoclastogenesis. These findings offer new therapeutic strategies for enhancing fracture repair via epigenetic regulation.
Authors
- Xinyu Zheng (ORCID: https://orcid.org/0000-0001-8425-3379)
- Yilun Pei (ORCID: https://orcid.org/0000-0001-7524-9730)
- Huijun Zhao (ORCID: https://orcid.org/0000-0002-3028-0459)
- Shangying Bai
- Shudong Xia (ORCID: https://orcid.org/0000-0001-6228-5783)
- Xinlin Yang (ORCID: https://orcid.org/0000-0002-1788-8347)
- Xingyu Li (ORCID: https://orcid.org/0000-0003-1653-4886)
- Jie Zhang (ORCID: https://orcid.org/0000-0001-7739-9257)
- Liang Liu (ORCID: https://orcid.org/0000-0002-7826-3877)
- Xuefei Wang
- Shan Lei (ORCID: https://orcid.org/0000-0002-2505-3059)
- Xuezhen Shen
- Hanchi Xu
- Junyi Shen
Institutions
- Capital Medical University (CN)
- Zhengzhou City Hospital (CN)
- Beijing Luhe Hospital Affiliated to Capital Medical University (CN)
- The Sixth People's Hospital of Zhengzhou (CN)
- University of Virginia (US)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.lfs.2025.123639
- Citations
- 6
- Primary Topic
- Magnesium Alloys: Properties and Applications
- Type
- article
- Field-Weighted Citation Impact
- 3.58