Malignant mesothelioma-associated inflammatory microenvironment promotes tumor progression via GPNMB
Overall, these results indicate that the protein GPNMB, a product and marker gene of TAMs, is a driver of mesothelioma progression and may constitute a promising therapeutic target.
Authors
- Cristina Belgiovine (ORCID: https://orcid.org/0000-0002-6986-9594)
- Luca Bertola (ORCID: https://orcid.org/0000-0003-0518-5748)
- Federica Marchesi (ORCID: https://orcid.org/0000-0002-7212-5721)
- Anna Rita Putignano (ORCID: https://orcid.org/0000-0002-6462-9188)
- Daniela Pistillo (ORCID: https://orcid.org/0000-0002-7665-3783)
- Fabio Grizzi (ORCID: https://orcid.org/0000-0003-0925-742X)
- Valentina Paleari
- Sonia Valentino (ORCID: https://orcid.org/0000-0001-8652-3168)
- Maurizio D’Incalci (ORCID: https://orcid.org/0000-0001-8784-1360)
- Paolo Andrea Zucali (ORCID: https://orcid.org/0000-0002-2274-1702)
- Paola Allavena (ORCID: https://orcid.org/0000-0002-6697-6028)
- Laura Mannarino (ORCID: https://orcid.org/0000-0002-0290-4228)
- Marco Erreni (ORCID: https://orcid.org/0000-0002-1922-0818)
- Fabio Pasqualini (ORCID: https://orcid.org/0000-0003-4852-3794)
- Elisabeth Digifico (ORCID: https://orcid.org/0000-0003-0107-1401)
- Camilla Recordati (ORCID: https://orcid.org/0000-0002-7172-9662)
- Alberto Mantovani (ORCID: https://orcid.org/0000-0001-6877-9848)
Institutions
- Humanitas University (IT)
- Queen Mary University of London (GB)
- University of Milan (IT)
- Biotechnology Research Center (IR)
- Fondazione Filarete (IT)
- William Harvey Research Institute (GB)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1186/s12967-025-06407-4
- Citations
- 4
- Primary Topic
- Graphene and Nanomaterials Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- Ministero della Salute
- Humanitas Research Hospital