Harmonization of quantitative liver function evaluation using gadoxetate disodium-enhanced magnetic resonance imaging

Question The accurate prediction of quantitative liver function by hepatocyte-specific contrast-enhanced MRI necessitates the harmonization of MR systems. However, no established method has yet been identified. Findings In quantitative hepatic function assessment, albumin-bilirubin linear predictor can be employed to achieve harmonization between MR systems equivalent to the indocyanine green clearance test. Clinical relevance Quantitative liver function, as measured by the indocyanine green clearance test, can be accurately estimated using the hepatocellular uptake index, harmonized with the albumin-bilirubin linear predictor, across diverse MR systems.