Shp-1 regulates the activity of low-affinity T cells specific to endogenous self-antigen during melanoma tumor growth and drives resistance to immune checkpoint inhibition
We conclude that approaches for altering TCR signaling threshold are effective in enhancing the antitumor response of low-affinity T cells specific for endogenous self-antigens in settings of ICI resistance and/or where neoantigens are not available to drive antitumor responses.
Authors
- Jacob N. Kisiolek (ORCID: https://orcid.org/0000-0003-2710-2237)
- Kaitlyn Flint (ORCID: https://orcid.org/0009-0006-0739-6900)
- Nico A Contreras
- Krystal R. Charley (ORCID: https://orcid.org/0000-0002-4065-1129)
- Jeremy P. Snook (ORCID: https://orcid.org/0000-0002-1396-9254)
- Ashleigh J. Soedel
- Elizabeth Motunrayo Kolawole (ORCID: https://orcid.org/0000-0003-3138-0037)
- Yohichi Kumaki
- Andrew G. Ramstead
- Matthew A. Williams (ORCID: https://orcid.org/0000-0002-4721-4482)
- Arnulfo Mendoza (ORCID: https://orcid.org/0009-0009-6082-9711)
- Brian D. Evavold (ORCID: https://orcid.org/0000-0002-3561-3494)
- Joseph G. Matous (ORCID: https://orcid.org/0000-0002-5000-7361)
- B. Robinson (ORCID: https://orcid.org/0009-0006-7467-2346)
Institutions
- Spelman College (US)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- North Carolina Agricultural and Technical State University (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-010879
- Citations
- 3
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National Institute of Allergy and Infectious Diseases
- DOD Peer Reviewed Cancer Research Program