Single-cell RNA sequencing of human double-negative T cells reveals a favorable cellular signature for cancer therapy
These results highlight the unique transcriptional, cellular, and functional profile of human DNTs and support the continued clinical investigation of allogeneic DNT therapy. The data also provide a reference gene signature that may help improve the efficacy of other types of allogeneic adoptive cellular therapies.
Authors
- Karen Fang (ORCID: https://orcid.org/0009-0001-6662-7872)
- Sergio Rutella (ORCID: https://orcid.org/0000-0003-1970-7375)
- Yoosu Na
- Enoch Tin (ORCID: https://orcid.org/0000-0001-7838-0400)
- Juanma Sánchez Arteaga (ORCID: https://orcid.org/0000-0001-6266-4038)
- Jongbok Lee (ORCID: https://orcid.org/0000-0002-0086-0938)
- Zhang Li (ORCID: https://orcid.org/0000-0003-4649-0757)
- Ismat Khatri
- Mark D. Minden
- Michele Nawata
Institutions
- University Health Network (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Nottingham Trent University (GB)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-010684
- Citations
- 3
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Canadian Institutes of Health Research