T-bet overexpression enhances CAR T cell effector functions and antigen sensitivity
Together, our data demonstrate that T-bet overexpression induces a reduction in Th2 cytokine production, an increase in polyfunctional Th1 cytokine production and enhances 4-1BB CAR T cell activity against cancers expressing low levels of target antigen without promoting a loss in functional CAR T cell persistence.
Authors
- Terry J. Fry (ORCID: https://orcid.org/0000-0001-8044-5226)
- Samuel D. Burciaga (ORCID: https://orcid.org/0000-0002-8707-260X)
- Amanda J Novak (ORCID: https://orcid.org/0009-0009-8780-7395)
- Michael Yarnell (ORCID: https://orcid.org/0000-0002-4557-7255)
- M. Eric Kohler (ORCID: https://orcid.org/0000-0002-1181-0418)
- Jennifer Cimons (ORCID: https://orcid.org/0000-0002-8111-8697)
- Kole DeGolier (ORCID: https://orcid.org/0000-0002-4144-7277)
- Amalia M Rivera-Reyes
Institutions
- Children's Hospital Colorado (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-010962
- Citations
- 4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Hyundai Hope On Wheels
- University of Colorado School of Medicine, Anschutz Medical Campus