TRIM25 facilitates ferroptosis in ovarian cancer through promoting PIEZO1 K63-linked ubiquitination and degradation
Our study clearly shows that TRIM25 stimulates ovarian cancer by inducing K63-linked ubiquitination of PIEZO1, which suppresses ferroptosis and promotes excessive proliferation of ovarian cancer cells. Further research identified the ubiquitination modification site on PIEZO1, providing insights for ovarian cancer treatment.
Authors
- Fei Zhou (ORCID: https://orcid.org/0000-0003-1216-2181)
- Zhengmei Xu
- Ya Li (ORCID: https://orcid.org/0000-0002-3633-469X)
Institutions
- Hengyang Normal University (CN)
- Hengyang Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1016/j.tranon.2025.102386
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94