Mixed brain pathology in neurodegenerative parkinsonism and dementia

Background: There is increasing evidence that high number of cases diagnosed clinically with phenotype, which corresponds to one of neurodegenerative proteinopathies (alpha-synucleinopathy, tauopathy, Alzheimeŕs disease (AD) related proteinopathy etc.) suffered actually from two or more neurodegenerative pathological processes. The aim of the study was to to assess the presence of mixed neurodegenerative pathology and its proportion in the prospective cohort of patients treated for any phenotype of neurodegenerative parkinsonism, in whom the diagnosis was done according to the validated clinical diagnostic criteria.