Design, synthesis and activity evaluation of dual-target inhibitors against papain-like and main proteases of porcine epidemic diarrhea virus
In summary, a potent dual-targeted inhibitor of PL<sup>pro</sup> and M<sup>pro</sup>, f2, was designed, synthesized, and found to be effective in the inhibition of PEDV replication and inflammatory response in vitro and in vivo.
Authors
- Dayong Shi (ORCID: https://orcid.org/0000-0001-8941-5285)
- Ruihua Liu (ORCID: https://orcid.org/0000-0002-2517-1581)
- Xing Pan (ORCID: https://orcid.org/0000-0002-8997-7840)
- Wenlong Shan
- Cong Shi (ORCID: https://orcid.org/0009-0000-5681-3834)
- Hongyun Qin (ORCID: https://orcid.org/0000-0003-4531-8330)
- Bo Wang (ORCID: https://orcid.org/0000-0002-8560-9071)
- Jiawen Zhu (ORCID: https://orcid.org/0000-0001-6279-9434)
- Chao Xie (ORCID: https://orcid.org/0009-0009-3645-5246)
- Chao Liu (ORCID: https://orcid.org/0000-0002-3632-2699)
- Xiangqian Li (ORCID: https://orcid.org/0000-0002-5807-5633)
- Zemin Wang
- Nan Zhou (ORCID: https://orcid.org/0000-0002-0393-316X)
- Zhuoya Wang (ORCID: https://orcid.org/0009-0003-1920-0061)
- Yuanyuan Zhao (ORCID: https://orcid.org/0000-0001-6002-8214)
- Jiashu Chen (ORCID: https://orcid.org/0000-0003-3222-1628)
- Yue Xu
- Yuxi Lin (ORCID: https://orcid.org/0000-0001-9284-2659)
- Weijian Zhuang (ORCID: https://orcid.org/0000-0002-0236-9624)
- Chenxia Gao
Institutions
- Shandong University (CN)
- Qingdao Center of Resource Chemistry and New Materials (CN)
- Shandong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.jare.2025.04.021
- Primary Topic
- Animal Virus Infections Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00