Acute Effect of High Fat Intake on Urinary Acidification Parameters
In conclusion, Ctrls showed reduced NH<sub>4</sub> <sup>+</sup> excretion with an acute fat load, consistent with substrate switch. However, UASFs demonstrated a chronic stable NH<sub>4</sub> <sup>+</sup> excretion defect consistent with lipotoxic impairment of proximal tubule function. Although dietary fat affects ammoniagenesis or excretion, dietary fat restriction alone is likely insufficient for managing the aciduria in UASFs.
Authors
- Orson W. Moe (ORCID: https://orcid.org/0000-0001-9176-3414)
- Alireza Zomorodian (ORCID: https://orcid.org/0000-0003-3298-0325)
- John Poindexter
- Naim M. Maalouf (ORCID: https://orcid.org/0000-0002-0997-283X)
- Khashayar Sakhaee (ORCID: https://orcid.org/0000-0001-8646-9579)
- Xilong Li (ORCID: https://orcid.org/0000-0002-1833-6077)
Institutions
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.ekir.2025.04.020
- Citations
- 1
- Primary Topic
- Renal function and acid-base balance
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Charles Pankow Foundation
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases