Longitudinal MRI Assessment of Brain Changes in Parkinson’s Disease
Background: Parkinson's disease (PD) is clinically heterogeneous, with REM sleep behavior disorder (RBD) playing a key role in subtyping forms of the disease. Proposed models of progression do not take all variations into account. We investigated the spatiotemporal brain changes in regions of interest (ROIs) associated with Braak stages of PD including brainstem, basal ganglia, thalamus and medial temporal lobe regions using MRI biomarkers and multivariate modelling to classify different disease trajectories
Authors
- Jean‐Christophe Corvol (ORCID: https://orcid.org/0000-0001-7325-0199)
- Nadya Pyatigorskaya (ORCID: https://orcid.org/0000-0002-2070-1299)
- Romain Valabrègue (ORCID: https://orcid.org/0000-0002-1814-9570)
- D. A. S. G. Mary (ORCID: https://orcid.org/0000-0003-4136-3556)
- Salim Ouarab
- Rahul Gaurav (ORCID: https://orcid.org/0000-0001-9983-5873)
- I. Arnulf
- J. Pérot (ORCID: https://orcid.org/0000-0002-6066-2909)
- Daniel Racoceanu (ORCID: https://orcid.org/0000-0002-9416-1803)
- M. Vidailhet
- François‐Xavier Lejeune (ORCID: https://orcid.org/0000-0002-6229-5364)
- Swann Ruyter
- Stéphane Lehéricy
- Gustavo Jiménez
- Esther Kozlowski
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut national de recherche en sciences et technologies du numérique (FR)
- Inserm (FR)
- Sorbonne Université (FR)
- Institut du Cerveau (FR)
- Université Paris 1 Panthéon-Sorbonne (FR)
Publication Details
- Journal
- Parkinsonism & Related Disorders
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.parkreldis.2025.107425
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00