Cellular and genetic changes during and after fluconazole exposure in Cryptococcus neoformans
These findings highlight that fluconazole influences the entire genome rather than specific chromosomes, which increases the heterogeneity in permanent changes after fluconazole removal. This heterogeneity may result in long-term consequences, including drug resistance.
Authors
- Samah H. I. Albehaijani
- Kylie J. Boyce (ORCID: https://orcid.org/0000-0002-7167-5414)
- Toan Huynh (ORCID: https://orcid.org/0000-0002-6455-3056)
Institutions
- Qassim University (SA)
- Buraydah Colleges (SA)
- MIT University (MK)
- RMIT University (AU)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.ijantimicag.2025.107519
- Citations
- 2
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- RMIT University
- Qassim University
- National Institutes of Health