The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ (Adv. Sci. 15/2025)
Fetal Growth restrictionTrophoblastic exosomes transport PPAR into fetal preadipocytes via fetoplacental circulation and thus participate in the transcriptional regulation of downstream genes, which is not identical to that of endogenous PPAR in preadipocytes.Compromised PPAR in the placenta causes deficient adipogenesis in the fetus and intruterine growth restriction but can be rescued by placenta-targeted activation of PPAR.More details can be found in article number 2404983 by Hongbo Qi, Chao Tong, and co-workers.
Authors
- Xia Yang (ORCID: https://orcid.org/0000-0002-4555-1522)
- Rodney E. Kellems (ORCID: https://orcid.org/0000-0001-8418-8116)
- Baozhen Zhang (ORCID: https://orcid.org/0000-0003-1719-4588)
- Philip N. Baker (ORCID: https://orcid.org/0000-0002-4592-6427)
- Jiayu Huang (ORCID: https://orcid.org/0000-0001-5195-1330)
- Hongbo Qi (ORCID: https://orcid.org/0000-0003-3776-0487)
- Xiaofang Luo (ORCID: https://orcid.org/0000-0003-4305-7616)
- Yong Fu (ORCID: https://orcid.org/0000-0001-6480-1147)
- Xiujun Fan (ORCID: https://orcid.org/0000-0003-3322-1857)
- Chao Tong (ORCID: https://orcid.org/0000-0003-0828-2674)
- Biao Huang (ORCID: https://orcid.org/0000-0003-1883-0670)
- Xiyao Liu (ORCID: https://orcid.org/0000-0003-2718-659X)
- Ping Xu (ORCID: https://orcid.org/0000-0002-3771-4758)
- Jiujiang Liao
- Mark D. Kilby (ORCID: https://orcid.org/0000-0001-9987-4223)
- Hao Wang (ORCID: https://orcid.org/0000-0002-1695-8825)
- Li Lin (ORCID: https://orcid.org/0000-0002-0132-5646)
- Mingyu Hu
Publication Details
- Journal
- Advanced Science
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/advs.202570108
- Citations
- 1
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.80