LIMA1 O‐GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β‐catenin‐Regulated FASn Expression in Metabolic Dysfunction‐Associated Steatotic Liver Disease (Adv. Sci. 15/2025)
Dysfunction-AssociAteD steAtotic Liver DiseAseHigh-fat diet upregulated O-GlcNAcylation of LIMA1 and LIMA1-enriched small extracellular vesicle (sEV) secretion in hepatocytes, exacerbated hepatic lipid deposition and metabolic dysfunction-associated steato-hepatitis (MASH) fibrosis.LIMA1 is a promising non-invasive biomarker and therapeutic target for MASH.
Authors
- Guojun Zheng (ORCID: https://orcid.org/0009-0000-8186-7359)
- Kefeng Gu
- Lin Fan
- Yongmin Yan (ORCID: https://orcid.org/0000-0002-1990-1170)
- Tingfen Li
- Fuji Yang
- Yifei Chen (ORCID: https://orcid.org/0000-0001-6644-4403)
- Ling Zhu (ORCID: https://orcid.org/0009-0003-7138-6561)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/advs.202570110
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00