Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress‐Associated Degradation of EZH2/MYC Axis (Adv. Sci. 15/2025)
Endoplasmic REticulum stREss REsponsESquamocin disrupts mitochondrial respiratory Complex I function, reduces ATP production, and impairs HSP90 function.These actions provoke endoplasmic reticulum (ER) stress and activate the unfolded protein response within tumor cells.This, in turn triggers the UBA6-UBE2Z-FBXW7 ubiquitin cascade, enhancing ER stress-associated ubiquitylation and degradation of EZH2 and MYC, ultimately resulting in tumor growth arrest.More details can be found in article number 2413120 by Yunshan Ning and co-workers.
Authors
- Haoran Cheng (ORCID: https://orcid.org/0000-0002-1736-1430)
- Yurui Liu
- Baojian Chen (ORCID: https://orcid.org/0000-0002-5933-1141)
- Bingxin Hu (ORCID: https://orcid.org/0000-0002-4067-4080)
- Tingting Tang (ORCID: https://orcid.org/0000-0002-1670-7452)
- Xinglong Liu (ORCID: https://orcid.org/0000-0002-1215-4117)
- Zhifeng Chen (ORCID: https://orcid.org/0000-0001-7824-373X)
- Xiangtao Wang (ORCID: https://orcid.org/0000-0003-1666-3039)
- Yunshan Ning (ORCID: https://orcid.org/0000-0002-3660-0249)
- Yin Zhu (ORCID: https://orcid.org/0000-0003-3504-5770)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/advs.202570109
- Citations
- 1
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.23