Improved Survival and Prognostication in Melanoma Patients With Brain Metastases: An Update of the Melanoma Graded Prognostic Assessment
Prognostic factors have changed and survival has improved for patients with MBM but varies widely by GPA. The updated Melanoma GPA calculator (BrainMetGPA), available free online, can be used to estimate survival, individualize treatment, stratify clinical trials, guide surveillance, and augment clinical trial eligibility. Multidisciplinary treatment is essential. Trials are needed to elucidate the optimal sequencing of various therapeutic modalities.
Authors
- Hussein A. Tawbi (ORCID: https://orcid.org/0000-0003-1942-851X)
- Michelle M. Kim (ORCID: https://orcid.org/0000-0001-7566-6411)
- Tuğçe Kütük (ORCID: https://orcid.org/0000-0003-0416-8612)
- Toshimichi Nakano (ORCID: https://orcid.org/0000-0001-5033-4509)
- Rupesh Kotecha (ORCID: https://orcid.org/0000-0001-6927-0402)
- Nayan Lamba (ORCID: https://orcid.org/0000-0002-2598-6529)
- Sean Sachdev (ORCID: https://orcid.org/0000-0001-7682-9673)
- Sanjay Aneja (ORCID: https://orcid.org/0000-0001-5681-7528)
- David Roberge (ORCID: https://orcid.org/0000-0001-8747-648X)
- Drexell H. Boggs (ORCID: https://orcid.org/0000-0003-1046-1671)
- Jared Pasetsky (ORCID: https://orcid.org/0009-0009-0789-8435)
- Kathryn E. Marqueen (ORCID: https://orcid.org/0000-0002-3077-677X)
- Tony J. C. Wang (ORCID: https://orcid.org/0000-0001-5809-3025)
- Minesh P. Mehta (ORCID: https://orcid.org/0000-0002-4812-5713)
- John M. Buatti (ORCID: https://orcid.org/0000-0001-8499-3721)
- Daniel K. Ebner (ORCID: https://orcid.org/0000-0001-6053-5865)
- Paul W. Sperduto (ORCID: https://orcid.org/0000-0002-4628-7161)
- Amandeep R. Mahal (ORCID: https://orcid.org/0000-0002-2631-1902)
- Helen Alice Shih (ORCID: https://orcid.org/0000-0003-1550-9726)
- Michael A. Davies (ORCID: https://orcid.org/0000-0002-0977-0912)
- Daniel Ellis Hyer (ORCID: https://orcid.org/0000-0002-7638-9599)
- Rifaquat Rahman (ORCID: https://orcid.org/0000-0002-9443-1797)
- Hany Soliman (ORCID: https://orcid.org/0000-0003-2824-2100)
- Donna M. Edwards (ORCID: https://orcid.org/0000-0001-7130-4755)
- Zihan Wan (ORCID: https://orcid.org/0009-0005-9359-6417)
- Salah Dajani
- Veronica Chiang (ORCID: https://orcid.org/0000-0003-1882-3876)
- Richard B. Ross (ORCID: https://orcid.org/0000-0002-9279-9168)
- Christina Phuong (ORCID: https://orcid.org/0000-0001-5854-0593)
- Steve E. Braunstein (ORCID: https://orcid.org/0000-0002-9841-9357)
- Donna Niedzwiecki (ORCID: https://orcid.org/0000-0002-3566-0450)
- Eugene Vaios (ORCID: https://orcid.org/0000-0003-2122-6650)
- William G. Breen (ORCID: https://orcid.org/0000-0001-8039-2398)
- Calvin D. Lewis (ORCID: https://orcid.org/0000-0003-2673-5884)
- John P. Kirkpatrick (ORCID: https://orcid.org/0000-0002-4019-0350)
- Chad G. Rusthoven (ORCID: https://orcid.org/0000-0002-6978-2077)
- Jing Li (ORCID: https://orcid.org/0000-0003-3654-9831)
- Enoch Chang (ORCID: https://orcid.org/0000-0002-2879-5445)
- Nii Ankrah
- Laura Masucci
- Fasila Johri
Institutions
- Northwestern University (US)
- University of Iowa (US)
- Brigham and Women's Hospital (US)
- Sunnybrook Health Science Centre (CA)
- The University of Texas MD Anderson Cancer Center (US)
- Duke University (US)
- University of California, San Francisco (US)
- University of Toronto (CA)
- University of Michigan (US)
- University of Alabama at Birmingham (US)
- Yale University (US)
- Massachusetts General Hospital (US)
- Baptist Health South Florida (US)
- Mayo Clinic in Arizona (US)
- Centre Hospitalier de l’Université de Montréal (CA)
- Columbia University (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1200/jco-24-01351
- Citations
- 6
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.11