Targeting LTBP2 Derived from Cancer-Associated Fibroblasts Sensitizes Esophageal Squamous Cell Carcinoma to Chemotherapy
CAF-secreted LTBP2 binds integrin α6β4 and activates Src signaling to drive metastasis and chemoresistance in esophageal cancer, highlighting LTBP2 as a key regulator of CAF-mediated tumor progression that can be therapeutically targeted.
Authors
- Ying‐Hui Zhu (ORCID: https://orcid.org/0000-0003-3403-6645)
- Jiarong Zhan
- Chen Jiang (ORCID: https://orcid.org/0000-0002-0245-0828)
- Xin‐Yuan Guan (ORCID: https://orcid.org/0000-0002-4485-6017)
- Mengqing Li (ORCID: https://orcid.org/0000-0002-0674-5623)
- Dan Xie (ORCID: https://orcid.org/0000-0003-2242-3138)
- Xin Wang (ORCID: https://orcid.org/0000-0003-1633-1712)
- Jun Liu (ORCID: https://orcid.org/0009-0009-1889-0535)
- Lei Li (ORCID: https://orcid.org/0000-0001-9910-5600)
- Qingyun Chen (ORCID: https://orcid.org/0000-0002-9726-8403)
- Ting-Ting Zeng
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Peking University Shenzhen Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1158/0008-5472.can-24-1816
- Citations
- 5
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 5.23