Mannose Enhances Immunotherapy Efficacy in Ovarian Cancer by Modulating Gut Microbial Metabolites
Alterations to the gut microbiome induced by mannose engender an immune stimulatory tumor microenvironment responsive to immunotherapy, suggesting that mannose may be an effective and safe adjuvant therapy for stimulating immunotherapy sensitivity.
Authors
- Congjian Xu (ORCID: https://orcid.org/0000-0002-7954-5892)
- Mengdi He (ORCID: https://orcid.org/0000-0003-2693-5261)
- Huan Yi (ORCID: https://orcid.org/0009-0009-9209-916X)
- Yiying Wang (ORCID: https://orcid.org/0000-0002-9661-6111)
- Chen Zhang (ORCID: https://orcid.org/0009-0005-1091-6316)
- Moran Yang (ORCID: https://orcid.org/0000-0002-0601-9090)
- Haiou Liu (ORCID: https://orcid.org/0000-0003-0200-8981)
- Kankan Cao (ORCID: https://orcid.org/0000-0001-9242-1440)
- Chenyang Wang (ORCID: https://orcid.org/0009-0007-6895-4897)
- Guodong Zhang (ORCID: https://orcid.org/0000-0002-9297-1335)
- Jiaqi Lu (ORCID: https://orcid.org/0000-0002-5646-0298)
- Yujing Zhong
- Xueling Wang
Institutions
- Fujian Medical University (CN)
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Fuzhou Maternity and Child Health Care Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3209
- Citations
- 11
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 8.87