Dynamic evolution and antitumor mechanisms of CXCR6+CD8+ T cells in small cell lung cancer treated with low-dose radiotherapy and immunotherapy
This study delineates the change trajectory of CD8<sup>+</sup> T cells, identifies the crucial role of DCs in T cell differentiation, and highlights the significance of tumor-specific CXCR6<sup>+</sup>CD8<sup>+</sup> T cells in anti-tumor immunity. Future therapeutic strategies for SCLC could focus on enhancing the infiltration of activated DCs and CXCR6<sup>+</sup>CD8<sup>+</sup> T cells within the tumor microenvironment to improve treatment efficacy.
Authors
- Zhuoran Yao (ORCID: https://orcid.org/0000-0002-1755-3563)
- Kai Kang (ORCID: https://orcid.org/0000-0002-8878-2080)
- You Lü (ORCID: https://orcid.org/0000-0003-1671-1408)
- Ren Luo (ORCID: https://orcid.org/0000-0003-2952-6543)
- Lin Guo (ORCID: https://orcid.org/0009-0005-2756-4302)
- Linglu Yi
Institutions
- Chengdu Medical College (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Sichuan Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s12967-025-06450-1
- Citations
- 6
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- Sichuan University
- West China Hospital, Sichuan University