Lianhua qingke alleviates cigarette smoke induced cellular senescence in COPD mice by regulating the Sp1/SIRT1/HIF-1α pathway
LHQK demonstrates potential as a complementary therapy for COPD, attenuating CS-triggered emphysema and pulmonary inflammation by targeting cellular senescence processes and modulation of Sp1/SIRT1/HIF-1α pathway.
Authors
- Zhancheng Gao (ORCID: https://orcid.org/0000-0001-7415-1416)
- Feng Cuiling (ORCID: https://orcid.org/0000-0001-5559-8431)
- Jianbo Xue
- Tongxing Wang (ORCID: https://orcid.org/0000-0002-4008-7230)
- Yixin Zhang (ORCID: https://orcid.org/0009-0006-9206-6454)
- Xianqiang Zhou (ORCID: https://orcid.org/0000-0003-4736-9123)
- Mengtong Jin
- Peng Liu (ORCID: https://orcid.org/0000-0003-1240-1672)
- Yan Yu (ORCID: https://orcid.org/0000-0003-0473-1794)
- YU Wei-dong (ORCID: https://orcid.org/0000-0002-3767-5066)
Institutions
- Shanxi Medical University (CN)
- Peking University (CN)
- Xian Central Hospital (CN)
- Shijiazhuang Academy of Agriculture and Forestry Sciences (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.jep.2025.119831
- Citations
- 2
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 2.45
Funders
- National Natural Science Foundation of China