Feasibility Study of an Indicator of Equivalent Potency of Multiple Anesthetics Normalized by Minimum Alveolar Concentration Derived From Response Surface Models
The eMAC fraction showed a superior performance in indicating the loss of response to electric stimulus compared to BIS. Anesthesiologists are familiar with the clinical use range of MAC fraction, and the distribution of eMAC fraction values during maintenance is similar to this range. This similarity allows anesthesiologists to easily use eMAC fraction in practice. These results indicate that the eMAC fraction has the potential to assist anesthesiologists in titrating multiple anesthetics to estimate the depth of anesthesia during general anesthesia, and should further be evaluated in clinical studies.
Authors
- Zhuomin Deng
- Hailong Dong (ORCID: https://orcid.org/0000-0001-8984-9067)
- Cynthia Wan (ORCID: https://orcid.org/0000-0001-6259-1449)
- Hao-Peng Zhang (ORCID: https://orcid.org/0000-0003-3265-9160)
- Zhenghua Zhu (ORCID: https://orcid.org/0000-0001-6208-1908)
- Jiuxiang Zhang
- Xin Li (ORCID: https://orcid.org/0000-0003-2525-9679)
- Yi Wang (ORCID: https://orcid.org/0000-0002-0192-3195)
- Wang Li (ORCID: https://orcid.org/0000-0002-2171-2205)
- Xiaohui Wang (ORCID: https://orcid.org/0000-0003-2370-1152)
- Fan Huang (ORCID: https://orcid.org/0000-0002-9767-089X)
- Shan He (ORCID: https://orcid.org/0000-0001-5743-7404)
Institutions
- Xijing Hospital (CN)
- Mindray (China) (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1213/ane.0000000000007514
- Citations
- 1
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 2.19